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Let‐7a elevates p21 WAF1 levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells
Author(s) -
He Xiaoyan,
Duan Changzhu,
Chen Junxia,
Ou-Yang Xi,
Zhang Zheng,
Li Chunlei,
Peng Huimin
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.10.007
Subject(s) - microrna , lung cancer , carcinogenesis , a549 cell , context (archaeology) , cancer research , in vivo , cell growth , biology , cancer , microbiology and biotechnology , chemistry , medicine , genetics , gene , paleontology
Down‐regulation of let‐7 microRNA (miRNA) is a key event in lung cancer. Despite recent advances in survival signaling, the roles of let‐7 in the context of lung cancer are not fully clear. In this study, we showed that let‐7a, a member of let‐7 family, negatively regulated the expression of NIRF through NIRF 3′ UTR. We also showed that NIRF was required for the let‐7a‐mediated elevation of p21 WAF1 . These findings suggest that growth‐inhibitory effect of let‐7a on the A549 cells in vitro and in vivo may be explained in part by le‐7a‐induced suppression of NIRF and elevation of p21 WAF1 . This work reveals a novel regulatory mechanism for let‐7a in the control of cellular proliferation and lung carcinogenesis.