Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species | Zendy

Rojas-Rivera Diego | Zendy; Díaz-Elizondo Jessica | Zendy; Parra Valentina | Zendy; Salas Daniela | Zendy; Contreras Ariel | Zendy; Toro Barbra | Zendy; Chiong Mario | Zendy; Olea-Azar Claudio | Zendy; Lavandero Sergio | Zendy

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Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species

Author(s) -

Rojas-Rivera Diego,

Díaz-Elizondo Jessica,

Parra Valentina,

Salas Daniela,

Contreras Ariel,

Toro Barbra,

Chiong Mario,

Olea-Azar Claudio,

Lavandero Sergio

Publication year - 2009

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2009.10.003

Subject(s) - reactive oxygen species , nifedipine , catalase , intracellular , chemistry , calcium , myocyte , necrosis , microbiology and biotechnology , medicine , oxidative stress , endocrinology , biochemistry , biology , organic chemistry

We investigated the role of Ca 2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo‐induced increases in cytoplasmic and mitochondrial Ca 2+ . Nifedipine (Nife) inhibited both Hypo‐induced Ca 2+ and ROS increases. Overexpression of catalase (CAT) induced RVD and a decrease in Hypo‐induced blebs. Nife prevented CAT‐dependent RVD activation. These results show a dual role of Hypo‐induced Ca 2+ influx in the control of cardiomyocyte viability. Hypo‐induced an intracellular Ca 2+ increase which activated RVD and inhibited necrotic blebbing thus favoring cell survival, while simultaneously increasing ROS generation, which in turn inhibited RVD and induced necrosis.

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