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System‐level design of bacterial cell cycle control
Author(s) -
McAdams Harley H.,
Shapiro Lucy
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.09.030
Subject(s) - cell cycle , microbiology and biotechnology , cell division , cell cycle protein , regulator , proteases , cell , restriction point , bacterial cell structure , biology , division (mathematics) , cell cycle progression , biochemistry , genetics , mathematics , bacteria , gene , enzyme , arithmetic
Understanding of the cell cycle control logic in Caulobacter has progressed to the point where we now have an integrated view of the operation of an entire bacterial cell cycle system functioning as a state machine. Oscillating levels of a few temporally‐controlled master regulator proteins in a cyclical circuit drive cell cycle progression. To a striking degree, the cell cycle regulation is a whole cell phenomenon. Phospho‐signaling proteins and proteases dynamically deployed to specific locations on the cell wall are vital. An essential phospho‐signaling system integral to the cell cycle circuitry is central to accomplishing asymmetric cell division.