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Time‐dependent regulation of muscle caveolin activation and insulin signalling in response to high‐fat diet
Author(s) -
Gómez-Ruiz Ana,
de Miguel Carlos,
Campión Javier,
Martínez J. Alfredo,
Milagro Fermín I.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.09.016
Subject(s) - insulin , signalling , endocrinology , medicine , chemistry , caveolin 1 , insulin response , caveolin 3 , microbiology and biotechnology , signal transduction , biology , biochemistry , caveolae , plasma glucose
We studied the effect of high‐fat diet on the expression and activation of the three caveolins in rat skeletal muscle and their association with the insulin signalling cascade. Initial response was characterized by increased signalling through Cav‐1 and Cav‐3 phosphorylation, suggesting that both participate in an initial acute response to the calorie surplus. Afterwards, Cav‐1 signalling was slightly reduced, whereas Cav‐3 remained active. Late chronic phase signalling through both proteins was impaired inducing a prediabetic state. Summarizing, caveolins seem to mediate a time‐dependent regulation of insulin cascade in response to high‐fat diet in muscle.