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Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob / ob mice
Author(s) -
Li Xiaofan,
Ge Hongfei,
Weiszmann Jennifer,
Hecht Randy,
Li Yue-sheng,
Véniant Murielle M.,
Xu Jing,
Wu Xinle,
Lindberg Richard,
Li Yang
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.09.012
Subject(s) - lipolysis , fgf21 , medicine , endocrinology , chemistry , energy homeostasis , hormone , adipocyte , glucose homeostasis , in vivo , adipose tissue , in vitro , fatty acid , fibroblast growth factor , biology , biochemistry , insulin , insulin resistance , obesity , receptor , microbiology and biotechnology
FGF21 is a unique member of the fibroblast growth factors (FGFs) and a novel hormone that regulates glucose, lipid, and energy homeostasis. The beneficial effects of FGF21 reported thus far have mostly been from chronic treatments. In order to better understand the mechanism for FGF21 action, we evaluated the acute effects of FGF21 in vivo and in vitro. Here we report that a single injection of FGF21 acutely reduced plasma free fatty acid levels similar to its acute effects on plasma glucose in ob / ob mice. In vitro, FGF21 inhibited lipolysis in adipocytes during a short treatment and reduced total lipase activity. These results demonstrate the potential importance of adipocyte lipolysis to the observed acute improvements in plasma parameters.