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Pleiotropic roles of calumenin ( calu‐1 ), a calcium‐binding ER luminal protein, in Caenorhabditis elegans
Author(s) -
Cho Jeong Hoon,
Song Hyun-Ok,
Singaravelu Gunasekaran,
Sung Hyun,
Oh Won-Chan,
Kwon Soonjae,
Kim Do Han,
Ahnn Joohong
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.08.018
Subject(s) - caenorhabditis elegans , endoplasmic reticulum , microbiology and biotechnology , biology , mutant , inositol , calcium binding protein , calcium signaling , calcium , receptor , signal transduction , chemistry , biochemistry , gene , organic chemistry
Calumenin is a Ca 2+ binding protein localizing at the lumen of the endoplasmic reticulum (ER). Although it has been implicated in various diseases, the in vivo functions of calumenin are largely unknown. Here, we report that calumenin has pleiotropic roles in muscle and cuticle function in Caenorhabditis elegans . Mutant analysis revealed that the calu‐1 is required for regulating fertility, locomotion and body size. In addition, calu‐1 is important for two behaviors, defecation and pharyngeal pumping, consistent with its ability to bind Ca 2+ . The genetic analysis further suggested the possibility that calu‐1 regulates the pharyngeal pumping together with the inositol 1,4,5‐triphosphate (IP 3 ) receptor encoded by itr‐1 . Taken together, our data suggest that calumenin is important for calcium signaling pathways in C. elegans .