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Lumcorin: A leucine‐rich repeat 9‐derived peptide from human lumican inhibiting melanoma cell migration
Author(s) -
Zeltz Cédric,
Brézillon Stéphane,
Perreau Corinne,
Ramont Laurent,
Maquart François-Xavier,
Wegrowski Yanusz
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.08.012
Subject(s) - lumican , peptide , melanoma , in vitro , chemistry , recombinant dna , cell culture , cell , cancer research , microbiology and biotechnology , biochemistry , biology , proteoglycan , genetics , extracellular matrix , gene , decorin
We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine‐rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lum ican cor e prote in ) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.