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A third functional isoform enriched in mushroom body neurons is encoded by the Drosophila 14‐3‐3ζ gene
Author(s) -
Messaritou Georgia,
Leptourgidou Flora,
Franco Maribel,
Skoulakis Efthimios M.C.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.08.003
Subject(s) - mushroom bodies , drosophila (subgenus) , gene isoform , gene , biology , rna interference , drosophila melanogaster , genetics , rna , microbiology and biotechnology
14‐3‐3 Proteins are highly conserved across eukaryotes, typically encoded by multiple genes in most species. Drosophila has only two such genes, 14‐3‐3ζ ( leo ), encoding two isoforms LEOI and LEOII, and 14‐3‐3ε. We report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas, thus increasing 14‐3‐3 diversity in Drosophila. Furthermore, we used a novel approach of spatially restricted leo abrogation by RNA‐interference and revealed differential LEO distribution in adult heads, with LEOIII enrichment in neurons essential for learning and memory in Drosophila.