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Heat shock protein 60: Evidence for receptor‐mediated induction of proinflammatory mediators during adipocyte differentiation
Author(s) -
Gülden Elke,
Märker Tina,
Kriebel Jennifer,
Kolb-Bachofen Victoria,
Burkart Volker,
Habich Christiane
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.07.049
Subject(s) - proinflammatory cytokine , heat shock protein , hsp60 , adipocyte , microbiology and biotechnology , receptor , chemistry , inflammation , biology , endocrinology , medicine , immunology , hsp70 , adipose tissue , biochemistry , gene
Adipocytes play important roles in lipid metabolism but also in the control of inflammatory processes. Based on our previous findings of heat shock protein (Hsp) 60‐induced activation of preadipocytes we investigated whether the capacity of heat shock protein 60 (Hsp60) to interact with adipocytes and to stimulate their proinflammatory activity is determined by the differentiation state of the cells. Hsp60 bound to adipocytes and stimulated the release of inflammatory mediators independent of their differentiation state. Hsp60‐adipocyte interactions revealed basic characteristics of a receptor‐mediated process. Our findings characterize Hsp60 binding and Hsp60‐induced release of proinflammatory mediators as fundamental properties of adipocytes independent of their differentiation state.