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The COPI system: Molecular mechanisms and function
Author(s) -
Beck R.,
Ravet M.,
Wieland F.T.,
Cassel D.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.07.032
Subject(s) - copi , copii , microbiology and biotechnology , vesicle , biogenesis , vesicular transport protein , golgi apparatus , biology , context (archaeology) , chemistry , secretory pathway , membrane , biochemistry , endoplasmic reticulum , paleontology , gene
Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers. Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the early secretory pathway. We focus on mechanisms mediating coat recruitment, uptake of cargo, vesicle budding and fission, and finally dissociation of the coat. In this context, recent findings on the interplay between machinery and auxiliary proteins in COPI vesicle formation and function will be discussed. Specifically, we will weigh the pros and cons of recent data on roles of the small GTP binding protein Arf1, of Arf1GAPs, and lipids during COPI carrier formation.