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Processed short neuropeptide F peptides regulate growth through the ERK‐insulin pathway in Drosophila melanogaster
Author(s) -
Lee Kyu-Sun,
Hong Seung-Hyun,
Kim Ae-Kyeong,
Ju Sung-Kyu,
Kwon O-Yu,
Yu Kweon
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.07.024
Subject(s) - drosophila melanogaster , mapk/erk pathway , insulin , neuropeptide , biology , microbiology and biotechnology , melanogaster , in vivo , peptide , drosophilidae , signal transduction , gene , biochemistry , endocrinology , genetics , receptor
The Drosophila sNPF gene regulates growth through the ERK‐insulin pathway. sNPF encodes a precursor protein that is processed and produces biologically active sNPF peptides. However, the functions of these peptides are not known. In Drosophila neuronal cells in culture and in flies in vivo, sNPF1 and sNPF2 activated the ERK‐insulin pathway and regulated body growth. In addition, the sNPF precursor and the processed sNPF peptide were co‐localized in the neurons of the central nervous system. These results indicate that sNPF1 and sNPF2 peptides processed from the sNPF precursor are sufficient for regulating body growth through the ERK‐insulin pathway in Drosophila .