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Cardiolipin‐enriched raft‐like microdomains are essential activating platforms for apoptotic signals on mitochondria
Author(s) -
Sorice Maurizio,
Manganelli Valeria,
Matarrese Paola,
Tinari Antonella,
Misasi Roberta,
Malorni Walter,
Garofalo Tina
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.07.018
Subject(s) - cardiolipin , raft , microbiology and biotechnology , mitochondrion , apoptosis , lipid raft , inner mitochondrial membrane , chemistry , cytochrome c , lipid microdomain , membrane , biology , biophysics , signal transduction , biochemistry , phospholipid , organic chemistry , copolymer , polymer
Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase‐8 on mitochondria. We hypothesize that these platforms may correspond to “raft‐like” microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in “raft‐like” microdomains could be to anchor caspase‐8 at contact sites between inner and outer membranes, facilitating its self‐activation, Bid cleavage and apoptosis execution. The role played by “raft‐like” microdomains in the apoptotic program could introduce a new task in the pathogenetic studies on human diseases associated with cardiolipin dismetabolism.