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Autocrine regulation of early embryonic development by the artemin‐GFRA3 (GDNF family receptor‐alpha 3) signaling system in mice
Author(s) -
Li Jing,
Klein Cynthia,
Liang Chenguang,
Rauch Rami,
Kawamura Kazuhiro,
Hsueh Aaron J.W.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.06.050
Subject(s) - autocrine signalling , glial cell line derived neurotrophic factor , paracrine signalling , gdnf family of ligands , microbiology and biotechnology , biology , neurotrophic factors , receptor , genetics
Development of early embryos is regulated by autocrine/paracrine factors. Analyzing the expression of polypeptide ligand–receptor pairs using DNA microarray datasets, we identified transcripts for artemin, a member of the GDNF (glial cell line‐derived neurotrophic factor) family, its receptor GFRA3 (GDNF family receptor‐alpha 3) and coreceptor RET. Here we report an autocrine/paracrine role of the artemin‐GFRA3 signaling system in regulating early embryonic development and apoptosis. Possible involvement of the MAP kinase signaling pathway was also demonstrated. The genome‐wide survey of ligand–receptor pairs and early embryo cultures provided a better understanding of autocrine/paracrine embryonic factors important for optimal blastocyst development.