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Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age‐related parameters in Drosophila
Author(s) -
Martin Ian,
Jones Melanie A.,
Grotewiel Mike
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.06.023
Subject(s) - sod1 , superoxide dismutase , nervous system , biology , drosophila (subgenus) , life span , microbiology and biotechnology , drosophila melanogaster , neuroscience , reactive oxygen species , rna interference , antioxidant , genetics , biochemistry , gene , rna , evolutionary biology
Superoxide dismutase 1 (SOD1) is an important antioxidant previously shown to impact life span in Drosophila . We examined the consequences of manipulating Sod1 expression throughout the body or in the nervous system or musculature on life span and age‐related locomotor impairment (ARLI) in Drosophila . Ubiquitous overexpression of SOD1 extended life span but did not substantially forestall ARLI, whereas ubiquitous knock‐down of Sod1 shortened life span and accelerated ARLI. Interestingly, neither overexpression of Sod1 nor expression of Sod1 RNAi in the nervous system or muscle altered life span or ARLI. Our studies suggest that the control of reactive oxygen species by SOD1 in tissues other than the nervous system and musculature support life span and ARLI in Drosophila .