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High‐fat diet induced adiposity and insulin resistance in mice lacking the myotonic dystrophy protein kinase
Author(s) -
Llagostera Esther,
Carmona Mari Carmen,
Vicente Meritxell,
Escorihuela Rosa María,
Kaliman Perla
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.05.043
Subject(s) - myotonic dystrophy , insulin resistance , endocrinology , medicine , knockout mouse , protein kinase a , insulin , biology , kinase , genetics , receptor
Myotonic dystrophy 1 (MD1) is caused by a CTG expansion in the 3′‐unstranslated region of the myotonic dystrophy protein kinase (DMPK) gene. MD1 patients frequently present insulin resistance and increased visceral adiposity. We examined whether DMPK deficiency is a genetic risk factor for high‐fat diet‐induced adiposity and insulin resistance using the DMPK knockout mouse model. We found that high‐fat fed DMPK knockout mice had significantly increased body weights, hypertrophic adipocytes and whole‐body insulin resistance compared with wild‐type mice. This nutrient–genome interaction should be considered by physicians given the cardiometabolic risks and sedentary lifestyle associated with MD1 patients.