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Apolipoprotein E limits oxidative stress‐induced cell dysfunctions in human adipocytes
Author(s) -
Tarnus Evelyne,
Wassef Hanny,
Carmel Jean-François,
Rondeau Philippe,
Roche Marjolaine,
Davig Jean,
Bernier Lise,
Bourdon Emmanuel
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.05.016
Subject(s) - oxidative stress , adipose tissue , adipocyte , apolipoprotein e , antioxidant , medicine , endocrinology , chemistry , oxidative phosphorylation , adipose tissue macrophages , intracellular , white adipose tissue , extracellular , microbiology and biotechnology , biology , biochemistry , disease
Oxidative stress in adipose tissue constitutes a pathological process involved in obesity‐linked metabolic disorders. Apolipoprotein E (apoE), which exhibits antioxidant properties in plasma and brain, is highly produced by adipose tissue and adipocytes. In this study, we investigated the role of apoE in the human adipocyte response to oxidative stress. We first demonstrated that apoE secretion by adipocytes was stimulated by oxidative stress. We also observed that apoE overexpression protected adipocytes from hydrogen peroxide‐induced damages, by mitigating intracellular oxidation and exerting extracellular antioxidant properties. Our findings clearly show a novel antioxidant role for apoE in adipose tissue.