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The yeast MAPK Hog1 is not essential for immediate survival under osmostress
Author(s) -
Maayan Inbal,
Engelberg David
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.05.014
Subject(s) - yeast , microbiology and biotechnology , chemistry , mapk/erk pathway , phosphorylation , biology , biochemistry
The yeast HOG pathway is activated in response to increased osmolarity and affects many cellular activities. As cells lacking Hog1 are osmo‐sensitive it is believed that Hog1 is essential for survival under osmostress. We show, however, that hog1 Δ cells survive and even proliferate to some degree under high osmostress for many hours. If forced to enter G1/G0 prior the exposure to osmostress, hog1 Δ cells survive for at least 6 days. We suggest that the primary role of Hog1 is not to preserve viability upon exposure to stress. We discuss the possibility that Hog1 is needed for proliferation under osmostress.