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From transcriptome analysis to immunogenomics: Current status and future direction
Author(s) -
Ohara Osamu
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.04.021
Subject(s) - complementary dna , computational biology , context (archaeology) , transcriptome , genomics , dna sequencing , biology , cdna library , functional genomics , data science , genetics , bioinformatics , genome , computer science , gene , gene expression , paleontology
In 1994, we pioneered a complementary DNA (cDNA) sequencing project that aimed to predict the primary structures of unknown human proteins. Although our cDNA project was focused on the sequencing of large cDNAs, the following cDNA sequencing projects conducted by other groups have more extensively characterized mammalian transcriptome. In parallel, many groups have made a tremendous amount of effort to develop various resources for functional human genomics. In this context, to demonstrate the power of functional genomic approaches in practice, we have applied them for a comprehensive understanding of the immune system, which we term ‘immunogenomics’. This mini‐review first describes the historical background of our cDNA project and then provides perspectives on the present and future of immunogenomics based on our experiences.