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TNF‐related apoptosis‐inducing ligand suppresses PRDX4 expression
Author(s) -
Wang Hua-Qin,
Du Zhen-Xian,
Liu Bao-Qin,
Gao Yan-Yan,
Meng Xin,
Guan Yifu,
Zhang Hai-Yan
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.04.009
Subject(s) - apoptosis , downregulation and upregulation , oxidative stress , programmed cell death , microbiology and biotechnology , ligand (biochemistry) , tumor necrosis factor alpha , endogeny , chemistry , gene expression , biology , gene , receptor , biochemistry , immunology
TNF‐related apoptosis‐inducing ligand (TRAIL) is currently considered a promising target for developing anti‐cancer therapies. Accumulating evidences have now shown that oxidative stress is involved in the TRAIL‐mediated cell death. The peroxiredoxins (PRDXs) are a ubiquitous family of proteins involved in protection against oxidative stress through the detoxification of cellular peroxides. Here we demonstrated that endogenous expression of PRDX4 was significantly decreased by TRAIL at the transcriptional level. In addition, overexpression of PRDX4 dramatically suppressed TRAIL‐induced apoptosis. Taken together, these data for the first time suggested that TRAIL suppressed the PRDX4 gene at the transcriptional level and that downregulation of PRDX4 might facilitate cell death induced by TRAIL.