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Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism
Author(s) -
Bae Eun-Ji,
Lee Hyun-Seob,
Park Chang-Hwan,
Lee Sang-Hun
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.04.004
Subject(s) - paracrine signalling , microbiology and biotechnology , nuclear receptor , embryonic stem cell , transcription factor , precursor cell , cellular differentiation , biology , neuron , midbrain , receptor , neuroscience , cell , chemistry , central nervous system , biochemistry , gene
Nurr1 is an orphan nuclear receptor‐type transcription factor (TF) that plays critical roles in midbrain dopamine neuron development. This study demonstrated a novel role for Nurr1 in neuronal/astrocytic differentiation of neural precursor (NP) cells isolated from rat embryonic cortices: overexpression of this TF promoted NP cell differentiation towards neurons at the expense of astrocytic differentiation. Single cell‐based lineage analyses and experiments using co‐cultures revealed that Nurr1 elicited its neurogenic role in an extrinsic paracrine manner. We defined diffusible factors and downstream neurogenic TFs responsible for the Nurr1‐mediated neuronal differentiation.