The  Plasmodium  HU homolog, which binds the plastid DNA sequence‐independent manner, is essential for the parasite's survival | Zendy

Sasaki Narie | Zendy; Hirai Makoto | Zendy; Maeda Katsura | Zendy; Yui Ryoko | Zendy; Itoh Kie | Zendy; Namiki Syoko | Zendy; Morita Teppei | Zendy; Hata Masayuki | Zendy; Murakami-Murofushi Kimiko | Zendy; Matsuoka Hiroyuki | Zendy; Kita Kiyoshi | Zendy; Sato Shigeharu | Zendy

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The Plasmodium HU homolog, which binds the plastid DNA sequence‐independent manner, is essential for the parasite's survival

Author(s) -

Sasaki Narie,

Hirai Makoto,

Maeda Katsura,

Yui Ryoko,

Itoh Kie,

Namiki Syoko,

Morita Teppei,

Hata Masayuki,

Murakami-Murofushi Kimiko,

Matsuoka Hiroyuki,

Kita Kiyoshi,

Sato Shigeharu

Publication year - 2009

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2009.03.071

Subject(s) - plasmodium berghei , biology , plastid , plasmodium falciparum , parasite hosting , genome , gene , genetics , plasmodium (life cycle) , malaria , apicomplexa , dna , computational biology , chloroplast , world wide web , computer science , immunology

The nuclear genome of the human malaria parasite Plasmodium falciparum encodes a homolog of the bacterial HU protein (PfHU). In this study, we characterised PfHU's physiological function. PfHU, which is targeted exclusively to the parasite's plastid, bound its natural target – the plastid DNA – sequence‐independently and complemented lack of HU in Escherichia coli . The HU gene could not be knocked‐out from the genome of Plasmodium berghei , implying that HU is important for the parasite's survival. As the human cell lacks the HU homolog, PfHU is a potential target for drugs to control malaria.

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