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Identification of LTR‐specific small non‐coding RNA in FeLV infected cells
Author(s) -
Forman Lora W.,
Pal-Ghosh Ruma,
Spanjaard Remco A.,
Faller Douglas V.,
Ghosh Sajal K.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.056
Subject(s) - rna , computational biology , identification (biology) , biology , microbiology and biotechnology , genetics , gene , botany
The U3‐LTR region of leukemia viruses transactivates cancer‐related signaling pathways through the production of a non‐coding RNA transcript although the role of this transcript in virus infection remains unknown. In this study we demonstrate for the first time that an long terminal repeat (LTR)‐specific small non‐coding RNA is produced from a feline leukemia virus (FeLV)‐infected feline cell line. RNA cloning identified this as a 104 base transcript that originates from the U3‐LTR region. We also demonstrate that in in vitro assays this LTR‐RNA transcript activates NFκB signaling. Taken together, our findings suggest a possible role for this LTR transcript in FeLV pathogenesis.