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When X‐inactivation meets pluripotency: An intimate rendezvous
Author(s) -
Navarro Pablo,
Avner Philip
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.043
Subject(s) - xist , reprogramming , homeobox protein nanog , sox2 , induced pluripotent stem cell , microbiology and biotechnology , blastocyst , inner cell mass , x inactivation , biology , epigenetics , epiblast , embryonic stem cell , rex1 , cell potency , genetics , embryo , gene , embryogenesis , x chromosome , gastrulation
The integration of X‐inactivation with development is a crucial aspect of this classical paradigm of epigenetic regulation. During early female mouse development, X‐inactivation reprogramming occurs in pluripotent cells of the inner cell mass of the blastocyst and in pluripotent primordial germ cells. Here we discuss the developmental strategies which ensure the coupling of the regulation of X‐inactivation to the acquisition of pluripotency through the regulation of the master of X‐inactivation, the non‐coding Xist gene, by the key factors which support pluripotency Nanog, Oct4 and Sox2.