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Challenges in cancer research and multifaceted approaches for cancer biomarker quest
Author(s) -
Martinkova Jirina,
Gadher Suresh Jivan,
Hajduch Marian,
Kovarova Hana
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.042
Subject(s) - cancer , biomarker discovery , multiplex , cancer biomarkers , proteomics , computational biology , biomarker , disease , bioinformatics , biology , medicine , genetics , gene
Recent advances in cancer biology have subsequently led to the development of new molecularly targeted anti‐cancer agents that can effectively hit cancer‐related proteins and pathways. Despite better insight into genomic aberrations and diversity of cancer phenotypes, it is apparent that proteomics too deserves attention in cancer research. Currently, a wide range of proteomic technologies are being used in quest for new cancer biomarkers with effective use. These, together with newer technologies such as multiplex assays could significantly contribute to the discovery and development of selective and specific cancer biomarkers with diagnostic or prognostic values for monitoring the disease state. This review attempts to illustrate recent advances in the field of cancer biomarkers and multifaceted approaches undertaken in combating cancer.