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Homocysteine and lipids: S‐Adenosyl methionine as a key intermediate
Author(s) -
Obeid Rima,
Herrmann Wolfgang
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.038
Subject(s) - homocysteine , hyperhomocysteinemia , hyperlipidemia , medicine , methionine , endocrinology , very low density lipoprotein , cholesterol , high density lipoprotein , chemistry , phospholipid , biochemistry , reverse cholesterol transport , lipoprotein , biology , diabetes mellitus , amino acid , membrane
An association between hyperlipidemia and hyperhomocysteinemia (HHCY) has been suggested. This link is clinically important in management of vascular risk factors especially in elderly people and patients with metabolic syndrome. Higher plasma homocysteine (Hcy) was associated with lower high‐density lipoprotein (HDL)‐cholesterol level. Moreover, HHCY was associated with disturbed plasma lipids or fatty liver. It seems that hypomethylation associated with HHCY is responsible for lipid accumulation in tissues. Decreased methyl group will decrease the synthesis of phosphatidylcholine, a major phospholipid required for very low‐density lipoprotein (VLDL) assembly and homeostasis. The effect of Hcy on HDL‐cholesterol is probably related to inhibiting enzymes or molecules participating in HDL‐particle assembly.