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Ca 2+ ‐modulated ONE‐GC odorant signal transduction
Author(s) -
Duda Teresa,
Sharma Rameshwar K.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.036
Subject(s) - second messenger system , signal transduction , intracellular , extracellular , transduction (biophysics) , chemistry , microbiology and biotechnology , biochemistry , receptor , biophysics , stereochemistry , biology
In a subset of olfactory epithelium the odorant receptor guanylate cyclase, ONE‐GC, is a central transduction component of the cyclic GMP signaling pathway. The odorant binds to the extracellular domain and activates its intracellular catalytic domain to generate the odorant second messenger, cyclic GMP. The present study demonstrates that it is a two‐step, Ca 2+ ‐independent and Ca 2+ ‐dependent, sequential process. In step one, the odorant, uroguanylin, binds ONE‐GC and primes it for stimulation. In step two, Ca 2+ ‐bound neurocalcin δ binds to the defined intracellular domain and saturates ONE‐GC activity. A prototype model is proposed that depicts this signal transduction process.