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The effect of 2‐deoxy‐ d ‐glucose on Werner syndrome RecQ helicase gene
Author(s) -
Zhou Bei,
Ikejima Takashi,
Watanabe Takeshi,
Iwakoshi Keiko,
Idei Yohei,
Tanuma Sei-ichi,
Uchiumi Fumiaki
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.033
Subject(s) - telomere , telomerase , recq helicase , helicase , werner syndrome , gene , premature aging , rna helicase a , microbiology and biotechnology , biology , chemistry , genetics , rna
Caloric restriction (CR) is known to effectively elongate mammalian life‐spans. The compound 2‐deoxy‐ d ‐glucose (2DG), which is often used as an inhibitor of glucose utilization, is a mimetic agent of CR. In this study, we examined the changes of telomerase and Werner's syndrome RecQ (WRN) helicase after treatment with 2DG, because of the involvement of recQ helicase in the regulation of telomeres. Interestingly, 2DG treatment increased the expression of WRN protein in accordance with induction of its promoter activity and gene expression. Furthermore, the activation of telomerase was observed after 2DG treatment, whereas it resulted in the reduction of cell proliferation. These results suggest that 2DG could up‐regulate telomere maintenance factors accompanied with suppression of proliferation.