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Induction of gene encoding FABP4 in Pten‐null keratinocytes
Author(s) -
Tsuda Masaaki,
Inoue-Narita Tae,
Suzuki Akira,
Itami Satoshi,
Blumenberg Miroslav,
Manabe Motomu
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.03.030
Subject(s) - pten , keratinocyte , phenotype , biology , fatty acid binding protein , gene
Keratinocyte‐specific Pten‐null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten‐null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte‐specific fatty acid‐binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte‐specific Pten‐null mice.