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Conserved recoding RNA editing of vertebrate C1q‐related factor C1QL1
Author(s) -
Sie Christina P.,
Maas Stefan
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.02.044
Subject(s) - rna editing , zebrafish , biology , rna , vertebrate , genetics , adar , computational biology , gene
A‐to‐I RNA editing can lead to recoding of pre‐mRNAs with profound functional consequences for the ensuing proteins. Here we show that complement component 1, q subcomponent‐like 1 (C1QL1) undergoes RNA editing in vivo causing non‐synonymous amino acid substitutions in human, mouse as well as zebrafish. The major editing site had previously been annotated as a single‐nucleotide polymorphism in human, but our analysis reveals that post‐transcriptional modification is the cause for the sequence variation. Remarkably, although editing of C1QL1 is conserved across vertebrate species, the predicted RNA secondary structure mediating editing involves different regions in zebrafish versus mammals.