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Putative role for ABC multidrug exporters in yeast quorum sensing
Author(s) -
Hlaváček Otakar,
Kučerová Helena,
Harant Karel,
Palková Zdena,
Váchová Libuše
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.02.030
Subject(s) - quorum sensing , yeast , transcription factor , biology , atp binding cassette transporter , transporter , multiple drug resistance , population , bacteria , microbiology and biotechnology , saccharomyces cerevisiae , gene , drug resistance , genetics , biofilm , medicine , environmental health
Pleiotropic drug resistance (PDR) transporters play essential roles in cell resistance to various toxic compounds in various organisms including bacteria, mammals and yeasts. A large group of PDR transporters have been described in yeasts so far, including those that are controlled by transcription factor Pdr1p. Here, we show that besides their role in removing extracellularly added toxic compounds, the Pdr5p and Snq2p transporters play important physiological roles and significantly influence the developmental phases and physiology of yeast populations growing in a liquid culture. They appear to be involved in population quorum sensing, which consequently influences transcription factor Pdr1p level via feedback regulation.