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pH‐Dependent Fe (II) pathophysiology and protective effect of an organoselenium compound
Author(s) -
Hassan Waseem,
Ibrahim Mohammad,
Deobald Anna Maria,
Braga Antonio Luiz,
Nogueira Cristina Wayne,
Rocha Joao B.T.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.02.020
Subject(s) - pathophysiology , chemistry , pharmacology , stereochemistry , medicine
Influence of pH on the extent of lipid peroxidation and the anti‐oxidant potential of an organoselenium compound is explored. Acidosis increased the rate of lipid peroxidation both in the absence and presence of Fe (II) in rat's brain, kidney and liver homogenate and phospholipids extract from egg yolk. The organoselenium compound significantly protected lipids from peroxidation, both in the absence and presence of Fe (II). Changing the pH of the reaction medium did not alter the anti‐oxidant activity of the tested compound. This study provides in vitro evidence for acidosis‐induced oxidative stress in brain, kidney, liver homogenate and phospholipids extract and the anti‐oxidant action of the tested organoselenium compound.