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Essential role of SBP‐1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans
Author(s) -
Taghibiglou Changiz,
Martin Henry G.S.,
Rose Jacqueline K.,
Ivanova Nadia,
Lin Conny H.C.,
Lau H. Lee,
Rai Susan,
Wang Yu Tian,
Rankin Catharine H.
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.01.045
Subject(s) - caenorhabditis elegans , transcription factor , sterol regulatory element binding protein , hypoxia (environmental) , microbiology and biotechnology , homeostasis , oxygen , biology , gene knockdown , endocrinology , medicine , chemistry , biochemistry , gene , organic chemistry
Epidemiological evidence suggests a link between chronic oxygen starvation and fat accumulation/obesity, however the underlying mechanism remains unclear. Using Caenorhabditis elegans we found extended oxygen deprivation resulted in activation of SBP‐1, the worm homologue of SREBP1, a transcription factor important in maintaining lipid homeostasis. SBP‐1 knockdown prevented hypoxia‐induced fat accumulation and the associated increase in worm width/length ratio, demonstrating that SBP‐1/SREBP1 plays an essential role in hypoxia‐induced lipid accumulation and body shape alteration. This study provides the first evidence suggesting that activation of SREBP1 may be a critical pathogenic factor contributing to chronic hypoxia associated excessive fat accumulation/obesity in humans.