Human Cdc25A phosphatase has a non‐redundant function in G2 phase by activating Cyclin A‐dependent kinases | Zendy

Timofeev Oleg | Zendy; Cizmecioglu Onur | Zendy; Hu Entan | Zendy; Orlik Thomas | Zendy; Hoffmann Ingrid | Zendy

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Human Cdc25A phosphatase has a non‐redundant function in G2 phase by activating Cyclin A‐dependent kinases

Author(s) -

Timofeev Oleg,

Cizmecioglu Onur,

Hu Entan,

Orlik Thomas,

Hoffmann Ingrid

Publication year - 2009

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2009.01.044

Subject(s) - kinase , cdc25a , phosphatase , microbiology and biotechnology , chemistry , cyclin dependent kinase , function (biology) , cyclin , biochemistry , phosphorylation , biology , cell cycle , cell cycle checkpoint , cell

Cdc25 phosphatases activate Cdk/Cyclin complexes by dephosphorylation and thus promote cell cycle progression. We observed that the peak activity of Cdc25A precedes the one of Cdc25B in prophase and the maximum of Cyclin/Cdk kinase activity. Furthermore, Cdc25A activates both Cdk1–2/Cyclin A and Cdk1/Cyclin B complexes while Cdc25B seems to be involved only in activation of Cdk1/Cyclin B. Concomitantly, repression of Cdc25A led to a decrease in Cyclin A‐associated kinase activity and attenuated Cdk1 activation. Our results indicate that Cdc25A acts before Cdc25B – at least in cancer cells, and has non‐redundant functions in late G2/early M‐phase as a major regulator of Cyclin A/kinase complexes.

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