Inducible expression of  Wnt  genes during adult hepatic stem/progenitor cell response | Zendy

Itoh Tohru | Zendy; Kamiya Yoshiko | Zendy; Okabe Mayuko | Zendy; Tanaka Minoru | Zendy; Miyajima Atsushi | Zendy

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Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response

Author(s) -

Itoh Tohru,

Kamiya Yoshiko,

Okabe Mayuko,

Tanaka Minoru,

Miyajima Atsushi

Publication year - 2009

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2009.01.022

Subject(s) - wnt signaling pathway , progenitor cell , microbiology and biotechnology , stem cell , biology , progenitor , signal transduction

In injured livers where hepatocyte growth is severely limited, facultative hepatic stem/progenitor cells, termed oval cells in rodents, are known to emerge and contribute to the regeneration process. Here, we investigated a possible involvement of Wnt signaling during mouse oval cell response and found significant upregulation of several Wnt genes including Wnt7a , Wnt7b , and Wnt10a . Accordingly, increase of β‐catenin protein was observed in oval cell compartments. Pharmacological activation of the canonical Wnt/β‐catenin signaling induced proliferation of cultured hepatic stem/progenitor cell lines. These results together implicate the role of Wnt/β‐catenin signaling in adult hepatic stem/progenitor cell response.

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