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Differential effects of triterpene glycosides, frondoside A and cucumarioside A 2 ‐2 isolated from sea cucumbers on caspase activation and apoptosis of human leukemia cells
Author(s) -
Jin Jun-O,
Shastina Valeria V.,
Shin Sung-Won,
Xu Qi,
Park Joo-In,
Rasskazov Valery A.,
Avilov Sergey A.,
Fedorov Sergey N.,
Stonik Valentin A.,
Kwak Jong-Young
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2009.01.010
Subject(s) - apoptosis , triterpene , xylose , glycoside , chemistry , programmed cell death , caspase , stereochemistry , monosaccharide , residue (chemistry) , biochemistry , biology , microbiology and biotechnology , medicine , alternative medicine , pathology , fermentation
Frondoside A is a pentaoside having an acetyl moiety at the aglycon ring and xylose as a third monosaccharide residue. Cucumarioside A 2 ‐2 is a pentaoside having glucose as a third monosaccahride unit. We compared the effects of frondoside A and A 2 ‐2 for cell death‐inducing capability with close attention paid to structure–activity relationships. Both frondoside A and A 2 ‐2 strongly induced apoptosis of leukemic cells. Frondoside A‐induced apoptosis was more potent and rapid than A 2 ‐2‐induced apoptosis. A 2 ‐2‐induced but not frondoside A‐induced apoptosis was caspase‐dependent. This suggests that holothurians may induce apoptosis of leukemic cells caspase‐dependently or ‐independently, depending on the holothurian structure.