ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT‐4 cells | Zendy

Fujimoto Takahiro | Zendy; Doi Keiko | Zendy; Koyanagi Midori | Zendy; Tsunoda Toshiyuki | Zendy; Takashima Yasuo | Zendy; Yoshida Yasuhiro | Zendy; Sasazuki Takehiko | Zendy; Shirasawa Senji | Zendy

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ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT‐4 cells

Author(s) -

Fujimoto Takahiro,

Doi Keiko,

Koyanagi Midori,

Tsunoda Toshiyuki,

Takashima Yasuo,

Yoshida Yasuhiro,

Sasazuki Takehiko,

Shirasawa Senji

Publication year - 2009

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.12.063

Subject(s) - apoptosis , gene knockdown , microbiology and biotechnology , biology , immune system , zinc finger , caspase , regulator , t cell , programmed cell death , gene , immunology , genetics , transcription factor

ZFAT (also known as ZNF406 ), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc‐finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT‐4 cells. Intriguing is that mouse ZFAT expression in CD4 + lymphocytes is increased during blast formation. Furthermore, ZFAT‐knockdown in MOLT‐4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune‐related cells.

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