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ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT‐4 cells
Author(s) -
Fujimoto Takahiro,
Doi Keiko,
Koyanagi Midori,
Tsunoda Toshiyuki,
Takashima Yasuo,
Yoshida Yasuhiro,
Sasazuki Takehiko,
Shirasawa Senji
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.12.063
Subject(s) - apoptosis , gene knockdown , microbiology and biotechnology , biology , immune system , zinc finger , caspase , regulator , t cell , programmed cell death , gene , immunology , genetics , transcription factor
ZFAT (also known as ZNF406 ), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc‐finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT‐4 cells. Intriguing is that mouse ZFAT expression in CD4 + lymphocytes is increased during blast formation. Furthermore, ZFAT‐knockdown in MOLT‐4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune‐related cells.