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Individual and common inhibitors of coronavirus and picornavirus main proteases
Author(s) -
Kuo Chih-Jung,
Liu Hun-Ge,
Lo Yueh-Kuei,
Seong Churl-Min,
Lee Kee-In,
Jung Young-Sik,
Liang Po-Huang
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.12.059
Subject(s) - picornavirus , proteases , protease , coronavirus , virology , covid-19 , biology , rna , enzyme , computational biology , chemistry , medicine , biochemistry , disease , gene , pathology , infectious disease (medical specialty)
Picornaviruses (PV) and coronaviruses (CoV) are positive‐stranded RNA viruses which infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. As reported in this study, using high throughput screening against ∼6800 small molecules, we have identified several novel inhibitors of SARS‐CoV 3CL pro with IC 50 of low μM. Interestingly, one of them equally inhibited both 3C pro and 3CL pro from PV and CoV, respectively. Using computer modeling, the structural features of these compounds as individual and common protease inhibitors were elucidated to enhance our knowledge for developing anti‐viral agents against PV and CoV.