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The mammalian nonsense‐mediated mRNA decay pathway: To decay or not to decay! Which players make the decision?
Author(s) -
Silva Ana Luísa,
Romão Luísa
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.12.058
Subject(s) - nonsense mediated decay , rna splicing , translation (biology) , enhancer , biology , messenger rna , repressor , microbiology and biotechnology , genetics , gene , gene expression , rna
Nonsense‐mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination codons (PTCs). Although the core process and several NMD effectors are conserved among species, the involvement of a splicing‐dependent signal seems to be specific for mammalian PTC definition. Still, recent data shed new light on physical parameters and mechanistic pathways involved in NMD. Here, we examine these findings, updating the roles for potential NMD players, such as the exon junction complex and the cytoplasmic poly(A)‐binding protein 1 – the former acting as enhancer rather than an essential factor and the latter functioning as NMD repressor.