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Zeb1‐mediated T‐cadherin repression increases the invasive potential of gallbladder cancer
Author(s) -
Adachi Yoshihiro,
Takeuchi Tamotsu,
Nagayama Tomoko,
Ohtsuki Yuji,
Furihata Mutsuo
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.12.042
Subject(s) - cadherin , gallbladder cancer , psychological repression , regulator , cancer research , gallbladder , biology , cancer , transcription factor , medicine , gene expression , gene , genetics , cell
Here, we report that the transcriptional regulator Zeb1 repressed the transcription of T‐cadherin, to increase the invasive activity of gallbladder cancer cells. Zeb1 physically bound to the promoter of T‐cadherin, repressed promoter activity in E‐box‐like sequence‐dependent fashion, and suppressed T‐cadherin expression. In gallbladder cancer tissues, Zeb1 was expressed at the cancer invasion front, whereas T‐cadherin was exclusively expressed in non‐invasive foci. Collagen gel invasion assay showed that T‐cadherin was a negative regulator for gallbladder cancer invasion. These findings suggest that Zeb1 represses T‐cadherin expression and thus increases the invasive activity of gallbladder cancer.