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The resetting of the circadian rhythm by Prostaglandin J 2 is distinctly phase‐dependent
Author(s) -
Koinuma Satoshi,
Yagita Kazuhiro,
Fujioka Atsuko,
Takashima Naoyuki,
Takumi Toru,
Shigeyoshi Yasufumi
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.12.035
Subject(s) - circadian rhythm , per1 , forskolin , circadian clock , reset (finance) , phase response curve , phase (matter) , rhythm , suprachiasmatic nucleus , endocrinology , clock , light effects on circadian rhythm , medicine , chemistry , biology , neuroscience , organic chemistry , stimulation , economics , financial economics
The circadian rhythm can be reset by a variety of substances. Prostaglandin J 2 (PGJ 2 ) is one such substance and resets the circadian rhythm in fibroblasts. In our current study, we examined the phase‐dependent phase shift following PGJ 2 treatment using a real‐time luciferase luminescence monitoring system. In the phase response curves, we observed 12 h differences in the times of peaks in comparison with the same analysis for forskolin. Quantification of clock gene mRNAs following PGJ 2 administration additionally revealed a rapid decrease in the Per1 , Rev‐erbAα and Dbp levels. Our current findings thus suggest that PGJ 2 resets the peripheral circadian clock via a mechanism that is distinct from that used by forskolin (FK).