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Dcp1a phosphorylation along neuronal development and stress
Author(s) -
Blumenthal Jacob,
Behar Leah,
Elliott Evan,
Ginzburg Irith
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.12.002
Subject(s) - phosphorylation , microbiology and biotechnology , function (biology) , messenger rna , chemistry , biology , biochemistry , gene
Decapping protein 1a (Dcp1a) is found in P‐bodies and functions in mRNA cap removal prior to its degradation. The function and binding partners of Dcp1a have been thoroughly studied, however its expression pattern is still unclear. In this study we have monitored Dcp1a expression along brain development, neuronal differentiation and during cellular stress. We found that Dcp1a is hyperphosphorylated under these physiological conditions. We followed our observations and identified the specific amino acid residues that are phosphorylated. These findings suggest a novel post‐translational modification that may influence the function of Dcp1a in response to various physiological cues.