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Ser‐His catalyses the formation of peptides and PNAs
Author(s) -
Gorlero Maçha,
Wieczorek Rafal,
Adamala Katarzyna,
Giorgi Alessandra,
Schininà Maria Eugenia,
Stano Pasquale,
Luisi Pier Luigi
Publication year - 2009
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.11.052
Subject(s) - dipeptide , peptide , chemistry , nucleic acid , macromolecule , amino acid , condensation , stereochemistry , histidine , combinatorial chemistry , biochemistry , physics , thermodynamics
The dipeptide seryl‐histidine (Ser‐His) catalyses the condensation of esters of amino acids, peptide fragments, and peptide nucleic acid (PNA) building blocks, bringing to the formation of peptide bonds. Di‐, tri‐ or tetra‐peptides can be formed with yields that vary from 0.5% to 60% depending on the nature of the substrate and on the conditions. Other simpler peptides as Gly‐Gly, or Gly‐Gly‐Gly are also effective, although less efficiently. We discuss the results from the viewpoint of primitive chemistry and the origin of long macromolecules by stepwise fragment condensations.