Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI | Zendy

Inoue Osamu | Zendy; Suzuki-Inoue Katsue | Zendy; Shinoda Daisuke | Zendy; Umeda Yasuto | Zendy; Uchino Masazumi | Zendy; Takasaki Sin-ichi | Zendy; Ozaki Yukio | Zendy

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Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI

Author(s) -

Inoue Osamu,

Suzuki-Inoue Katsue,

Shinoda Daisuke,

Umeda Yasuto,

Uchino Masazumi,

Takasaki Sin-ichi,

Ozaki Yukio

Publication year - 2009

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.11.026

Subject(s) - gpvi , chemistry , platelet , platelet membrane glycoprotein , collagen receptor , integrin , glycoprotein , platelet adhesiveness , platelet activation , disintegrin , tyrosine phosphorylation , biochemistry , biophysics , phosphorylation , receptor , platelet aggregation , immunology , biology , enzyme , metalloproteinase

Novel synthetic collagen fibers, poly(PHG) made by polycondensation of Pro‐Hyp‐Gly, spontaneously assume polymeric structure with molecular weights greater than 10 5 . Its application for biomaterials has been explored, but that for a platelet agonist has not been investigated. Poly(PHG)‐induced platelet aggregation independently of thromboxane A 2 and integrin α2β1. Poly(PHG)‐induced tyrosine phosphorylation of glycoprotein VI (GPVI)‐related molecules and failed to activate GPVI/FcRγ‐deficient platelets. Binding of GPVI to poly(PHG) was confirmed by a surface plasmon resonance spectroscopy, suggesting that poly(PHG) activates platelets through GPVI. Poly(PHG) is an useful research tool to investigate GPVI‐mediated signals and a substitute for collagen in platelet functional assays.

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