Endogenous microRNAs induced by heat‐shock reduce myocardial infarction following ischemia–reperfusion in mice | Zendy

Yin Chang | Zendy; Wang Xiaoyin | Zendy; Kukreja Rakesh C. | Zendy

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Endogenous microRNAs induced by heat‐shock reduce myocardial infarction following ischemia–reperfusion in mice

Author(s) -

Yin Chang,

Wang Xiaoyin,

Kukreja Rakesh C.

Publication year - 2008

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2008.11.014

Subject(s) - cardioprotection , microrna , ischemia , shock (circulatory) , heat shock protein , myocardial infarction , endogeny , reperfusion injury , apoptosis , pharmacology , medicine , chemistry , biology , cardiology , gene , biochemistry

We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat‐shock (HS) showed a significant increase of miRNA‐1, miRNA‐21 and miRNA‐24 in the heart. miRNAs isolated from HS mice and injected into non‐HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro‐apoptotic genes and increase in anti‐apoptotic genes. Chemically synthesized miRNA‐21 also reduced infarct size, whereas a miRNA‐21 inhibitor abolished this effect. Overall, these studies for the first time provide evidence for the potential role of endogenously synthesized miRNA's in cardioprotection following I/R injury.

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