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Endogenous microRNAs induced by heat‐shock reduce myocardial infarction following ischemia–reperfusion in mice
Author(s) -
Yin Chang,
Wang Xiaoyin,
Kukreja Rakesh C.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.11.014
Subject(s) - cardioprotection , microrna , ischemia , shock (circulatory) , heat shock protein , myocardial infarction , endogeny , reperfusion injury , apoptosis , pharmacology , medicine , chemistry , biology , cardiology , gene , biochemistry
We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat‐shock (HS) showed a significant increase of miRNA‐1, miRNA‐21 and miRNA‐24 in the heart. miRNAs isolated from HS mice and injected into non‐HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro‐apoptotic genes and increase in anti‐apoptotic genes. Chemically synthesized miRNA‐21 also reduced infarct size, whereas a miRNA‐21 inhibitor abolished this effect. Overall, these studies for the first time provide evidence for the potential role of endogenously synthesized miRNA's in cardioprotection following I/R injury.