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A putative physiological role of hypothalamic CNTF in the control of energy homeostasis
Author(s) -
Vacher C.-M.,
Crépin D.,
Aubourg A.,
Couvreur O.,
Bailleux V.,
Nicolas V.,
Férézou J.,
Gripois D.,
Gertler A.,
Taouis M.
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.10.018
Subject(s) - ciliary neurotrophic factor , energy homeostasis , endogeny , endocrinology , hypothalamus , medicine , homeostasis , food intake , arcuate nucleus , receptor , biology , obesity , body weight , arc (geometry) , energy expenditure , geometry , mathematics , neurotrophic factors
Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high‐sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.