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The evolution of BIR domain and its containing proteins
Author(s) -
Cao Lihuan,
Wang Zhenghan,
Yang Xianmei,
Xie Li,
Yu Long
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.09.058
Subject(s) - xiap , novelty , biology , domain (mathematical analysis) , apoptosis , microbiology and biotechnology , inhibitor of apoptosis , divergence (linguistics) , evolutionary biology , computational biology , genetics , caspase , programmed cell death , philosophy , mathematics , theology , mathematical analysis , linguistics
BIR domain and its containing proteins play critical roles in cell apoptosis and cell division. Here several lines of novelty were revealed based on a comprehensive evolutionary analysis of BIR domains in 11 representative organisms. First, the type II BIR domains in Survivin and Bruce showed more conservation compared with the type I BIR domains in the inhibitors of apoptosis proteins (IAPs). Second, cIAP was derived from a XIAP duplicate and emerged just after the divergence of invertebrates and vertebrates. Third, the three BIR domains of NAIP displayed significantly elevated evolutionary rates compared with the BIR domains in other IAPs.