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Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
Author(s) -
Oishi Katsutaka,
Uchida Daisuke,
Ishida Norio
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.09.046
Subject(s) - fgf21 , endocrinology , medicine , bezafibrate , circadian rhythm , lipolysis , ketogenesis , peroxisome proliferator activated receptor , receptor , circadian clock , nuclear receptor , biology , chemistry , metabolism , fibroblast growth factor , biochemistry , adipose tissue , gene , transcription factor , ketone bodies
Peroxisome proliferator‐activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes associated with lipid metabolism. Recent studies have suggested that the expression of PPARα‐dependent fibroblast growth factor 21 (FGF21) plays important roles in adaptation to fasting, such as lipolysis and ketogenesis. We found that a nighttime injection of bezafibrate, a ligand of PPARα, effectively induced FGF21 expression, whereas a daytime injection did not affect it. Furthermore, bezafibrate‐induced circadian FGF21 expression was abolished in PPARα‐deficient mice. These observations suggest that bezafibrate‐induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARα system in the liver.