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Mitochondria and l ‐lactate metabolism
Author(s) -
Passarella Salvatore,
de Bari Lidia,
Valenti Daniela,
Pizzuto Roberto,
Paventi Gianluca,
Atlante Anna
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.09.042
Subject(s) - mitochondrion , metabolism , biochemistry , chemistry , biology , microbiology and biotechnology
We review here the novel insights arisen from investigations on l ‐lactate metabolism in mammalian, plant and yeast mitochondria. The presence of l ‐lactate dehydrogenases inside mitochondria, where l ‐lactate enters in a carrier‐mediated fashion, suggests that mitochondria play an important role in l ‐lactate metabolism. Functional studies have demonstrated the occurrence of several l ‐lactate carriers. Moreover, immunological investigations have proven the existence of monocarboxylate translocator isoforms in mitochondria.