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Vitamin E dependent microRNA regulation in rat liver
Author(s) -
Gaedicke Sonja,
Zhang Xiangnan,
Schmelzer Constance,
Lou Yijia,
Doering Frank,
Frank Jan,
Rimbach Gerald
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.09.032
Subject(s) - microrna , gene expression , biology , regulation of gene expression , in vivo , gene , messenger rna , vitamin , endocrinology , medicine , microbiology and biotechnology , biochemistry , genetics
Dietary vitamin E (VE) is known to regulate gene expression by altering mRNA concentrations. Recently, microRNA (miRNA) have been discovered as a means of posttranscriptional gene regulation. Since the effect of VE on miRNA regulation is unknown, we fed rats for 6 months diets deficient or sufficient in VE and determined hepatic concentrations of miRNA involved in processes previously associated with VE (lipid metabolism, miRNA‐122a; cancer and inflammation, miRNA‐125b). VE‐deficiency resulted in reduced concentrations of miRNA‐122a and miRNA‐125b. The findings of the present study demonstrate that differences in dietary VE may affect hepatic miRNA concentrations in vivo.