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Dexamethasone increases angiopoietin‐1 and quiescent hematopoietic stem cells: A novel mechanism of dexamethasone‐induced hematoprotection
Author(s) -
Kim Hyongbum,
Choi Ji-Young,
Lee Jung Min,
Park Yoon Shin,
Suh Hwal,
Song Hae-Ryong,
Jo Sangmee Ahn,
Jo Inho
Publication year - 2008
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2008.09.021
Subject(s) - dexamethasone , haematopoiesis , angiopoietin 2 , mechanism (biology) , angiopoietin , stem cell , chemistry , microbiology and biotechnology , cancer research , pharmacology , endocrinology , biology , vegf receptors , physics , vascular endothelial growth factor , quantum mechanics
Angiopoietin‐1 (Ang‐1) is known to have hematoprotective effects by increasing the quiescence of hematopoietic stem cells. However, it remains to be determined if the upregulation of Ang‐1 and the subsequent increase in the quiescence of hematopoietic stem cells are also involved in the dexamethasone (Dex)‐mediated bone marrow protection. Here Western blotting and flow cytometric analyses demonstrate that Dex increases the levels of Ang‐1 in mouse bone marrow and the quiescence of hematopoietic stem cells. Our data for the first time suggest that the increased quiescence of hematopoietic stem cells provides a novel mechanism of Dex‐induced hematoprotection.